Osteoarthritis (OA) is a chronic degenerative condition, affecting articular hyaline cartilage (cartilage that covers the ends of bones and provides a cushion as well as a slick surface for movement). Osteoarthritis occurs when this cartilage starts to wear down. Although most common in the knee joint, Osteoarthritis can occur in other joints like shoulder, hip as well. As a result, the bones rub together, causing pain, swelling and loss of function; such as stiffness or reduced range of motion in theÂ joints. Osteoarthritis accounts for profound morbidity, pain and health care expenses and is a major cause of disability. The consequences to the individual and to the population as a whole are very significant, particularly within the aging population with an estimated prevalence of 10% of the world’s population age 60 years and older. Conventional therapies for Osteoarthritis include nonsteroidal anti-inflammatory drugs (NSAIDS), injections of corticosteroids (anti-inflammatory hormones) into the joint, injections of hyaluronic acid (lubricant) into the joint, topical creams and gels, braces, massage, acupuncture, and physical therapy. These therapies for Osteoarthritis only address the symptoms, and do nothing to cure the disease. Surgical interventions include Arthroscopy, Osteotomy or Arthroplasty (Joint replacement) that are invasive, complicated and expensive. There are very few validated interventions that improve the clinical condition of a patient once the degenerative process becomes symptomatic.