EnPLAF is a technology to derive beneficial biological factors from patient's own blood platelets. EnPLAF products are rich in growth factors but do not contain any live cells. Our innovative EnPLAF technology is able to harvest and utilize the regenerative power of beneficial biological factors (proteins) secreted by a patient's own blood cells. When used as directed, EnPLAF products stimulate faster healing and regeneration as well as reduce pain, and inflammation.
Since EnPLAF is derived from the patient's own blood, there is no risk of having an allergic reaction from EnPLAF administration. This cutting-edge technology is a result of several years of research and development by our scientific team. EnPLAF is the spearhead of the future of medical advancement we've all been waiting for.
The cells in our body perform a variety of functions mostly in conjunction with other cells of the body. Our cells are capable of effectively communicating with one another through molecules called as growth factors and cytokines. These molecules are biologically active factors that the cells use to communicate with each other either by directly releasing it on each other or into the blood stream (autocrine, paracrine or endocrine). Therefore, these biologically active factors are essentially messengers that direct and help the cells do their required functions. These factors in fact pretty much define what the target cells should do. Their commands could lead the cells to grow, multiply and produce new cells, or even produce cell death if that cell is old and unwanted (something called as 'programmed cell death' or 'apoptosis').
NeoKine has developed the method of deriving beneficial biological factors (EnPLAF) directly from patient's blood. During natural healing of an injury (acute or chronic) it is possible that beneficial factors are not always available in required numbers at the injured site, whereby healing is either delayed, or it never occurs. By delivering EnPLAF to the affected area we can help to augment the natural healing process which then stimulates faster healing and regeneration as well as reduce pain, and inflammation.
Science behind EnPLAF
EnPLAF technology harnesses the regenerative power of beneficial biological factors secreted by activated platelets, making EnPLAF products completely non-cellular.
Evidence from scientific research shows that stem cells of all kinds (including blood platelets, adipose stem cells, bone marrow stem cells etc.) require the growth factors secreted by these cells to induce healing and regeneration. This is called paracrine action of stem cells where they release these beneficial growth factors at site of injury. The cells themselves do not survive in this external environment but it is these growth factors and cytokines that help healing and regeneration. In fact, scientists have been trying very hard to develop technologies to derive such growth factors from cells.
We have perfected this technology through years of research to develop our EnPLAF platform. We are now using this technology platform to launch several wound healing and regenerative medicine products that will be a giant step towards the future of personalized medicine.
The beneficial biological factors secreted by Platelets known to be important in healing, regeneration and pain reduction are:
- Platelet-derived growth factor (PDGF)
Cell growth, Collagen production, new generation and repair of blood vessels
- Vascular Endothelial Growth Factor (VEGF)
Growth and new generation of vascular endothelial cells
- Fibroblast Growth Factor (FGF)
Tissue repair, Cell growth, Collagen production
- Epidermal Growth Factor (EGF)
Epithelial cell growth, promotion of wound healing, angiogenesis
- Transforming Growth Factor beta1 (TGF-B)
Growth of epithelial cells, endothelial cells, promotion of wound healing
- Keratinocyte Growth Factor (KGF)
Growth and new generation of keratinocytes
Advantages of using EnPLAF
Below are the several advantages of using EnPLAF over conventional therapies for different diseases. EnPLAF
- Promotes faster healing and regeneration
- Is harvested naturally from the patient's own body
- Has longer lasting effect
- Is minimally invasive
- Has minimal side effects
- Has minimal to no down time
- Can be stored for future use without losing potency
- Single visit to the doctor can give you multiple EnPLAF which can be given over time for therapy
EnPLAF based therapies provide convenient, safe, cost-effective, and highly efficacious therapy options for patients in several conditions including
- Orthopedics and Pain management
- Podiatry and Wound healing
- Aesthetic medicine, Hair Restoration, Breast Rejuvenation
- Sexual Health